The frequency with which the water needs to be changed depends on various factors. This includes the number of cats drinking from it, the room temperature, and the location of the fountain. At least once a week, however, all the water should be replaced and the cat drinking fountain should be cleaned. On most models, the bowl can be easily removed, emptied, and cleaned under running water.
As with a conventional water bowl, cat hair, saliva, and dust settle in the basin of the drinking fountain. You should change the water and clean the basin as soon as you see any dirt lining the bowl, if not sooner. In general, the more often you change the water, the better.